初步研究去甲芬氟拉明对人脂肪组织体外脂生成的影响。
A preliminary study of the effect of norfenfluramine on lipogenesis by human adipose tissue in vitro.
机构信息
Clinical Research Centre, Watford Road, Harrow, Middlesex.
出版信息
Br J Clin Pharmacol. 1974 Oct;1(5):413-6. doi: 10.1111/j.1365-2125.1974.tb00279.x.
1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much higher than normal blood levels of the drug. 3 There was no correlation between the degree of inhibition by norfenfluramine in vitro and fat cell size, age or relative weight of the subject. Greater degrees of inhibition were however associated with samples of tissue from patients with higher blood glycerol concentrations and lower blood triglyceride concentrations.
去甲芬氟拉明被认为是人类体内芬氟拉明的主要活性代谢物。因此，研究了其对 12 名患者脂肪组织的体外脂肪生成作用。
尽管已经证明了脂肪生成的抑制作用，但所需的去甲芬氟拉明浓度（>1mM）远高于药物的正常血液水平。
体外去甲芬氟拉明的抑制程度与脂肪细胞大小、年龄或受试者的相对体重之间没有相关性。然而，与甘油浓度较高和三酰甘油浓度较低的患者组织样本相比，抑制程度更大。
Zotero 插件