Bizzi A, Tacconi M T, Tognoni G, Morselli P L, Garattini S
Int J Obes. 1978;2(1):1-5.
Concentrations of fenfluramine and its metabolite, norfenfluramine, were measured in blood, brain and parametrial adipose tissues 15, 30, 60 and 120 min after intraperitoneal (i.p.) administration of fenfluramine hydrochloride (10 mg/kg) to normal and gold-thioglucose obese mice. Concentrations of fenfluramine were higher in the brain of obese mice than in normal mice, while there was no difference in norfenfluramine levels in the two groups. This difference may be related to higher blood levels of fenfluramine but not of norfenfluramine in obese animals. The drug was presented in about the same concentrations in the adipose tissue of the two groups. These results may explain previous findings that fenfluramine was more effective as an anorectic agent in obese than in lean mice.
向正常小鼠和金硫葡萄糖诱导的肥胖小鼠腹腔注射盐酸芬氟拉明（10mg/kg）后15、30、60和120分钟，测量血液、大脑和子宫旁脂肪组织中芬氟拉明及其代谢产物去甲芬氟拉明的浓度。肥胖小鼠大脑中芬氟拉明的浓度高于正常小鼠，而两组去甲芬氟拉明水平无差异。这种差异可能与肥胖动物血液中芬氟拉明水平较高有关，而去甲芬氟拉明水平不高。两组脂肪组织中该药物的浓度大致相同。这些结果可能解释了之前的发现，即芬氟拉明作为一种食欲抑制剂在肥胖小鼠中比在瘦小鼠中更有效。
