Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
Br J Clin Pharmacol. 1974 Dec;1(6):499-504. doi: 10.1111/j.1365-2125.1974.tb01701.x.
1 Changes in pressor responses to infused noradrenaline and in triceps surae jerk amplitude have been measured after the i.v. administration of: chlorpromazine, thioridazine, prochlorperazine, dimethothiazine, indoramin, benzoctamine and clonidine. 2 Each of the drugs blocked pressor responses to noradrenaline and reduced triceps surae jerk amplitude, but little correlation was found between their potencies in the two systems. 3 The effects of the drugs on the triceps surae jerk are not incompatible with an action at a spinal α-adrenoceptor site, but other pharmacological factors may be involved, such as penetration of the drugs into the central nervous system, and differences in their uptake(1) blocking activity.
静脉注射氯丙嗪、硫利达嗪、丙氯拉嗪、二甲噻嗪、吲达胺、苯氧丙胺和可乐定后，测量了加压反应对输注去甲肾上腺素的变化和三头肌反射幅度。
每种药物均能阻断去甲肾上腺素的加压反应，并降低三头肌反射幅度，但在这两个系统中，它们的效价之间相关性不大。
药物对三头肌反射的影响与在脊髓 α-肾上腺素能受体部位的作用并不矛盾，但可能涉及其他药理因素，如药物渗透入中枢神经系统以及它们的摄取（1）阻断活性的差异。
