人体肌腱反射的肾上腺素能控制
Adrenergic control of tendon jerk reflexes in man.
作者信息
Phillips S J, Richens A, Shand D G
出版信息
Br J Pharmacol. 1973 Mar;47(3):595-605. doi: 10.1111/j.1476-5381.1973.tb08190.x.
Abstract
- Tendon jerk responses and H reflexes were recorded from conscious human volunteers before and after intravenous injection of methylamphetamine, thymoxamine and propranolol, and during intravenous infusion of noradrenaline.2. Methylamphetamine produced a significant increase in the amplitude of the tendon jerk, whereas noradrenaline had no effect in doses which caused a greater pressor response than methylamphetamine.3. Thymoxamine produced a dose-related reduction in the tendon jerk.4. Propranolol had no significant effect on the jerk.5. None of these drugs significantly affected the H reflex.6. It is suggested that central adrenoceptors, possibly alpha in type, exist in man, and that stimulation of these receptors facilitates tendon jerk reflexes by an action on the fusimotor system.
摘要
在清醒的人类志愿者静脉注射甲基苯丙胺、百里胺和普萘洛尔之前和之后，以及静脉输注去甲肾上腺素期间，记录了腱反射反应和H反射。
甲基苯丙胺使腱反射的幅度显著增加，而去甲肾上腺素在引起比甲基苯丙胺更大的升压反应的剂量下没有作用。
百里胺使腱反射产生剂量相关的降低。
普萘洛尔对腱反射没有显著影响。
这些药物均未对H反射产生显著影响。
提示人类存在中枢肾上腺素能受体，可能为α型，刺激这些受体通过对肌梭运动系统的作用促进腱反射。
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