Holland C L, Malasky C, Ogunkoya A, Bielory L
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark.
Chest. 1990 Dec;98(6):1518-9. doi: 10.1378/chest.98.6.1518.
A 45-year-old black woman, sputum positive for acid-fast bacilli, developed hypersensitivity to both isoniazid and rifampin. She was admitted to the hospital and desensitized to both medications using modified penicillin protocols. Skin testing was negative to both drugs. Desensitization to isoniazid was complicated by a drug fever that was controlled by prednisone. The patient was able to maintain once-a-day dosing without incident even with steroid taper. To our knowledge, this is the first reported case of dual isoniazid and rifampin hypersensitivity with rapid oral desensitization.
一名45岁的黑人女性，痰涂片抗酸杆菌阳性，对异烟肼和利福平均出现过敏反应。她入院后采用改良青霉素方案对这两种药物进行脱敏治疗。两种药物的皮肤试验结果均为阴性。异烟肼脱敏过程中出现药物热，使用泼尼松后得到控制。即使在逐渐减少类固醇用量的情况下，患者仍能每日一次给药且无不良反应。据我们所知，这是首例报告的同时对异烟肼和利福平过敏且通过快速口服脱敏成功治疗的病例。
