Department of Infectious Diseases, AP-HP Hôpital Saint-Louis, Denis Diderot - Paris 7 University, France.
Clin Microbiol Infect. 2012 Jun;18(6):E185-7. doi: 10.1111/j.1469-0691.2012.03819.x. Epub 2012 Mar 28.
We report a retrospective study of 24 patients with haematological malignancy and hepatosplenic candidiasis. Clinical and biological features were similar to previous reports. No patient previously received antifungal prophylaxis. Liver or spleen histological examination revealed yeasts in 6/24 patients (25%) on direct examination but all cultures were negative. After a median duration of 7 months, antifungal treatment was discontinued in 58% of the patients with no relapse. Eleven (46%) patients died during follow up. After multivariate analysis, independent factors associated with death were the duration of neutropenia (p 0.022) and relapsing haematological malignancy (p 0.015).
我们报告了 24 例血液系统恶性肿瘤合并肝脾念珠菌病患者的回顾性研究。临床和生物学特征与以往报道相似。所有患者均未接受过抗真菌预防治疗。6/24 例（25%）患者的肝脏或脾脏组织学检查直接检查发现酵母菌，但所有培养均为阴性。在中位 7 个月的治疗后，58%的患者停止了抗真菌治疗，无复发。11 例（46%）患者在随访期间死亡。多因素分析显示，与死亡相关的独立因素是中性粒细胞减少持续时间（p=0.022）和血液系统恶性肿瘤复发（p=0.015）。
