4th team of Cadet Brigade, Third Military Medical University, Chongqing 400038, China.
Metabolism. 2012 Sep;61(9):1321-9. doi: 10.1016/j.metabol.2012.02.010. Epub 2012 Mar 28.
Studies investigating the association between cytochrome P450 1B1 (CYP1B1) Asn453Ser (453 A/G, rs1800440) polymorphism and colorectal cancer (CRC) risk report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline and Embase Databases. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP1B1 polymorphism and CRC were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. The pooled ORs were performed for co-dominant model (GG vs AA, GA vs AA), dominant model (GG+GA vs AA), and recessive model (GG vs GA+AA). This meta-analysis included 7 case-control studies, which included 6375 CRC cases and 7003 controls. Overall, the variant genotypes (GG and GA) of the 453 A/G were not associated with CRC risk when compared with the wild-type AA homozygote (GG vs AA, OR=0.94, 95% CI=0.77-1.14; GA vs AA, OR=0.99, 95% CI=0.87-1.12). Similarly, no associations were found in the dominant and recessive models (dominant model, OR=0.98, 95% CI=0.87-1.09; recessive model, OR=0.94, 95% CI=0.77-1.14). When stratifying for country, study sample size, matched control and source of controls, no evidence of significant association was observed in any subgroup, except among those studies from "Canada". No publication bias was found in the present study. No association was found between the CYP1B1 Asn453Ser polymorphism and risk of CRC among Caucasians.
研究调查细胞色素 P450 1B1（CYP1B1）Asn453Ser（453A/G，rs1800440）多态性与结直肠癌（CRC）风险之间的关联，报告结果相互矛盾。本研究的目的是定量总结这种关系的证据。两位研究者独立检索了 Medline 和 Embase 数据库。当适当时，使用固定效应模型（Mantel-Haenszel 方法）和随机效应模型（DerSimonian 和 Laird 方法）计算 CYP1B1 多态性与 CRC 的汇总优势比（OR）和 95%置信区间（95%CI）。对于共显性模型（GG 与 AA、GA 与 AA）、显性模型（GG+GA 与 AA）和隐性模型（GG 与 GA+AA），进行了合并的 OR 分析。本荟萃分析纳入了 7 项病例对照研究，包括 6375 例 CRC 病例和 7003 例对照。总体而言，与野生型 AA 纯合子相比，453A/G 的变异基因型（GG 和 GA）与 CRC 风险无关（GG 与 AA，OR=0.94，95%CI=0.77-1.14；GA 与 AA，OR=0.99，95%CI=0.87-1.12）。同样，在显性和隐性模型中也未发现相关性（显性模型，OR=0.98，95%CI=0.87-1.09；隐性模型，OR=0.94，95%CI=0.77-1.14）。按国家、研究样本量、匹配对照和对照来源进行分层时，除了来自“加拿大”的研究外，在任何亚组中均未发现有统计学意义的相关性。本研究未发现发表偏倚。在高加索人群中，CYP1B1 Asn453Ser 多态性与 CRC 风险之间没有关联。
