Shafy Abdel, Molinié Vincent, Cortes-Morichetti Miguel, Hupertan Vincent, Lila Nermine, Chachques Juan C
Laboratory of Biosurgical Research, Alain Carpentier Foundation, University Paris Descartes, 75015 Paris, France.
ISRN Cardiol. 2012;2012:326809. doi: 10.5402/2012/326809. Epub 2012 Mar 14.
Adenosine and inosine are both key intracellular energy substrates for nucleotide synthesis by salvage pathways, especially during ischemic stress conditions. Additionally they both possess cell protective and cell repair properties. The objective of this study is to detect potential advantages of the combination of adenosine and inosine versus each drug alone, in terms of ventricular function, infarct size reduction and angiogenesis. Myocardial ischemia was created in rodents and treated with adenosine, inosine or their combination. Results of experiments showed that the combination of both drugs significantly reduced infarct size and improved myocardial angiogenesis and ventricular function. The two compounds, while chemically similar, use different intracellular pathways, allowing for complementary biological activities without overlapping. The drug combination at specific 1 : 5 adenosine : inosine dose ratio demonstrated positive cardiologic effects, deserving further evaluation as an adjunct to reperfusion techniques during and after acute coronary syndrome. The association of adenosine and inosine may contribute to reduce myocardial infarction morbidity and mortality rates.
腺苷和肌苷都是通过补救途径进行核苷酸合成的关键细胞内能量底物，尤其是在缺血应激条件下。此外，它们都具有细胞保护和细胞修复特性。本研究的目的是检测腺苷和肌苷联合使用相对于单独使用每种药物在心室功能、梗死面积减小和血管生成方面的潜在优势。在啮齿动物中制造心肌缺血，并分别用腺苷、肌苷或它们的组合进行治疗。实验结果表明，两种药物联合使用可显著减小梗死面积，改善心肌血管生成和心室功能。这两种化合物虽然化学结构相似，但使用不同的细胞内途径，从而实现互补的生物学活性而不重叠。特定1∶5腺苷∶肌苷剂量比的药物组合显示出积极的心脏学效应，作为急性冠状动脉综合征期间和之后再灌注技术的辅助手段值得进一步评估。腺苷和肌苷的联合使用可能有助于降低心肌梗死的发病率和死亡率。
