玻璃体内注射雷珠单抗治疗施特吕姆佩尔-洛林综合征中的脉络膜新生血管。
Intravitreal ranibizumab injection for choroidal neovascularization in Strümpell-Lorrain Syndrome.
作者信息
Tran T H C, Baglin G, Querques G
机构信息
Service d'ophtalmologie, université Catholique de Lille, hôpital Saint-Vincent-de-Paul, boulevard Belfort, BP 387, 59020 Lille cedex, France.
出版信息
J Fr Ophtalmol. 2012 May;35(5):353-5. doi: 10.1016/j.jfo.2011.12.004. Epub 2012 Mar 30.
Strümpell-Lorrain syndrome, or hereditary spastic paraplegia is a genetic disease of the central nervous system affecting the spinal cord and cerebellum. It represents a clinically heterogenous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. Ocular abnormalities include keratitis, macular pigmentary abnormalities, juxtafoveolar retinal telangiectasis and choroidal neovascularization. We report the first case of choroidal neovascularization associated with Strüpell-Lorrain syndrome treated successfully with intravitreal ranibizumab injection.
施特吕姆佩尔-洛兰综合征，即遗传性痉挛性截瘫，是一种影响脊髓和小脑的中枢神经系统遗传病。它代表了一组临床异质性的神经退行性疾病，其特征为下肢进行性痉挛和反射亢进。眼部异常包括角膜炎、黄斑色素异常、黄斑旁视网膜毛细血管扩张和脉络膜新生血管形成。我们报告了首例经玻璃体内注射雷珠单抗成功治疗的与施特吕姆佩尔-洛兰综合征相关的脉络膜新生血管形成病例。
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