Department of Gastroenterology, Centre Hospitalier Universitaire de Liège, Liège, Belgium.
J Crohns Colitis. 2012 Feb;6 Suppl 2:S260-7. doi: 10.1016/S1873-9946(12)60506-6.
Innovative ideas are required to improve the management of inflammatory bowel disease and to share best practice that can be implemented into clinical practice today. The use of biomarkers such as calprotectin to monitor disease progression and treatment response could help to improve management of inflammatory bowel disease, but several strategies need to be implemented to make this a reality in clinical practice. The use of calprotectin as a biomarker and the manipulation of the thiopurine pathway to extend the use of current therapies are examples of how basic research can translate into patient benefit. Translational research into the use of microbiota and predictive factors for response and toxicity to drugs, may provide future clinical applications. Global improvement in care in inflammatory bowel disease could also be advanced by improving service provision. For example, the establishment of 'Centres of Excellence', a global interactive inflammatory disease map, and the alignment of processes and standards of care within treatment centres may help to achieve better outcomes for patients with inflammatory bowel disease. Realization of this goal, as well as a better understanding of the aetiology of the disease, may be furthered by collaborative efforts between organizations involved in inflammatory bowel disease as well as wider collaboration across countries and globally.
需要创新理念来改善炎症性肠病的管理,并分享今天可以付诸临床实践的最佳实践。使用生物标志物(如钙卫蛋白)来监测疾病进展和治疗反应,可以帮助改善炎症性肠病的管理,但需要实施一些策略才能使其在临床实践中成为现实。使用钙卫蛋白作为生物标志物以及操纵硫嘌呤途径来延长现有治疗方法的使用,就是基础研究如何转化为患者获益的例子。对微生物组和对药物反应和毒性的预测因素的转化研究,可能为未来的临床应用提供依据。通过改善服务提供,也可以推动炎症性肠病护理的全球改善。例如,建立“卓越中心”、全球互动炎症性疾病地图,以及调整治疗中心的流程和护理标准,可能有助于改善炎症性肠病患者的治疗效果。通过参与炎症性肠病的组织之间的协作,以及更广泛的国家间和全球间的合作,实现这一目标,并进一步了解疾病的病因,可能会取得更大的进展。