Sipponen Taina, Kolho Kaija-Leena
HYKS, Meilahden Sairaala, Gastroenterologian Klinikka.
Duodecim. 2011;127(24):2631-7.
Calprotectin is a protein released especially from neutrophilic leukocytes and secreted into the intestine during inflammation of the intestinal mucosa. It can be assayed from the feces. Faecal calprotectin has proven to be a useful marker in the diagnostics and monitoring of inflammatory bowel diseases, and application of the assay has been extended from pediatric patients also to adults. Faecal calprotectin is highly elevated in active inflammatory bowel disease, and elevated values in symptomless patients seem to be predictive of exacerbation especially in ulcerative colitis and in Crohn's disease colitis.
钙卫蛋白是一种尤其从中性粒细胞释放出来的蛋白质，在肠黏膜炎症期间分泌到肠道中。它可以从粪便中检测出来。粪便钙卫蛋白已被证明是炎症性肠病诊断和监测中的一种有用标志物，该检测方法的应用也已从儿科患者扩展到成人。在活动性炎症性肠病中，粪便钙卫蛋白水平会大幅升高，无症状患者中该值升高似乎预示着病情会加重，尤其是在溃疡性结肠炎和克罗恩病结肠炎中。
