边缘性脑炎与谷氨酸脱羧酶 65 (GAD65) 自身免疫性 1 型糖尿病：大剂量静脉注射免疫球蛋白治疗有效。
Limbic encephalitis and type 1 diabetes with glutamic acid decarboxylase 65 (GAD65) autoimmunity: improvement with high-dose intravenous immunoglobulin therapy.
机构信息
Post-Emergency Unit, Department of Internal Medicine, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny cedex, France.
出版信息
Diabetes Metab. 2012 Jun;38(3):273-5. doi: 10.1016/j.diabet.2012.02.005. Epub 2012 Mar 29.
PMID:22463975
Abstract
Glutamic acid decarboxylase antibodies (GAD-abs) are an immunological factor involved in type 1 diabetes and other diseases involving the central nervous system. This report is of a patient with type 1 diabetes and a rare case of non-paraneoplastic limbic encephalitis mediated by anti-GAD65 antibodies that improved with the use of immunosuppressive drugs.
摘要
谷氨酸脱羧酶抗体（GAD-abs）是一种与 1 型糖尿病和其他涉及中枢神经系统的疾病有关的免疫因子。本报告介绍了一例 1 型糖尿病患者，其罕见的非副肿瘤性边缘叶脑炎由抗 GAD65 抗体介导，使用免疫抑制剂治疗后得到改善。
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