Unit of Clinical Pharmacology, Department of Clinical Sciences, University Hospital Luigi Sacco, Università di Milano, 20157 Milan, Italy.
Ital J Pediatr. 2012 Mar 30;38(1):11. doi: 10.1186/1824-7288-38-11.
Oxatomide at therapeutic doses generates occasionally drowsiness in children. When administered at toxic doses, however oxatomide may induce long lasting impaired consciousness. We now report a case of severe long lasting impaired consciousness induced by therapeutic doses of oxatomide occurring in a child affected by acute gastroenteritis. The clinical symptoms, the pharmacogenetic tests of polymorphisms in cytochrome P450 metabolizing enzymes (CYPs) and the clinical and laboratory analyses indicate that the enhanced drug sedative effect is likely due to an acute, yet mild, inflammatory state of the patient. These findings highlight the importance of assessing common, not serious inflammatory states when oxatomide is prescribed in paediatric patients.
奥沙米特在治疗剂量下偶尔会使儿童产生困倦。然而，当给予中毒剂量时，奥沙米特可能会导致长时间的意识障碍。我们现在报告一例因急性胃肠炎而发生在儿童身上的由奥沙米特治疗剂量引起的严重、持久的意识障碍病例。临床症状、细胞色素 P450 代谢酶（CYPs）多态性的遗传药理学检测以及临床和实验室分析表明，药物镇静作用增强可能是由于患者处于急性但轻度的炎症状态。这些发现强调了在给儿科患者开奥沙米特时评估常见但不严重的炎症状态的重要性。
