Department of Pathology, Erciyes University, Faculty of Medicine, 38039 Kayseri, Turkey.
Pathol Res Pract. 2012 May 15;208(5):281-5. doi: 10.1016/j.prp.2012.02.002. Epub 2012 Mar 29.
CD10 is known to be expressed in certain types of leukemia, in lymphomas and also in various types of carcinoma. However, data regarding CD10 expression in soft tissue sarcomas is scarce. Two hundred and two retrospective soft tissue sarcoma specimens were evaluated for CD10 expression immunohistochemically. The clinical records of these patients were reviewed, and clinical data was obtained for all patients. Our results showed that 90 of the 202 cases were found to express CD10. 72% of malignant fibrous histiocytomas, 45% of fibrosarcomas, 34% of rhabdomyosarcomas, 50% of leiomyosarcomas, 22% of liposarcomas, 72% of malignant peripheral nerve sheath tumors, and 0% of the primitive neuroectodermal tumors were positive for CD10. Nearly half of the soft tissue sarcomas were found to express CD10. Stronger CD10 expression was found in high grade sarcomas.
CD10 已知在某些类型的白血病、淋巴瘤以及各种类型的癌中表达。然而，关于 CD10 在软组织肉瘤中的表达的数据很少。我们对 202 例回顾性软组织肉瘤标本进行了 CD10 免疫组化表达评估。回顾了这些患者的临床记录，并获得了所有患者的临床数据。我们的结果显示，202 例中有 90 例表达 CD10。72%的恶性纤维组织细胞瘤、45%的纤维肉瘤、34%的横纹肌肉瘤、50%的平滑肌肉瘤、22%的脂肪肉瘤、72%的恶性周围神经鞘瘤和 0%的原始神经外胚层肿瘤为 CD10 阳性。将近一半的软组织肉瘤被发现表达 CD10。高级别肉瘤中 CD10 的表达更强。
