二乙基二硫代氨基甲酸盐导致小鼠大脑对铜和锌的摄取增加。
Increased brain uptake of copper and zinc in mice caused by diethyldithiocarbamate.
作者信息
Aaseth J, Søli N E, Førre O
出版信息
Acta Pharmacol Toxicol (Copenh). 1979 Jul;45(1):41-4. doi: 10.1111/j.1600-0773.1979.tb02358.x.
Abstract
Mice given 64CuCl2 and 65ZnCl2 (10 mumol/kg) were treated with sodium diethyldithiocarbamate (0.5 mmol/kg). The treatment increased the brain level of radioactive copper five-fold and that of radioactive zinc three-fold. Such redistribution of metal ions may be explained from the formation of lipophilic metal chelates. The increased brain levels may involve neurotoxic effects.
摘要
给小鼠注射64CuCl2和65ZnCl2（10微摩尔/千克）后，用二乙基二硫代氨基甲酸钠（0.5毫摩尔/千克）进行处理。该处理使脑中放射性铜的水平增加了五倍，放射性锌的水平增加了三倍。金属离子的这种重新分布可能是由于亲脂性金属螯合物的形成。脑中水平的升高可能涉及神经毒性作用。
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