Palazzi M, Abramson D H, Ellsworth R M
Escola Paulista de Medicina, São Paulo, Brazil.
J Pediatr Ophthalmol Strabismus. 1990 Sep-Oct;27(5):255-8. doi: 10.3928/0191-3913-19900901-10.
A retrospective review of 297 cases of enucleated and histologically proven unilateral retinoblastoma with a minimum of 5-year follow-up was analyzed to see if there were any clinical or prognostic differences between endophytic and exophytic type retinoblastoma. Endophytic retinoblastoma (181 cases) was found more often than exophytic (116 cases). The following features were not associated with the clinical appearance of either endophytic or exophytic tumors: sex of patient, right vs left eye, propensity for bilateral development, initial sign or symptom, presence of rubeosis, preoperative metastasis, optic nerve invasion, orbital recurrence, survival of the patient, length of follow-up, or age at diagnosis. Three features were found that correlated with type: a disproportionately higher percentage of patients with endophytic retinoblastoma had a positive family history; a disproportionately high percentage of patients with exophytic retinoblastoma developed glaucoma; and choroidal invasion occurred significantly more often in patients who had exophytic retinoblastoma than in those who had endophytic retinoblastoma.
对297例经眼球摘除术且组织学确诊为单侧视网膜母细胞瘤并至少随访5年的病例进行回顾性分析，以观察内生型和外生型视网膜母细胞瘤之间是否存在临床或预后差异。内生型视网膜母细胞瘤（181例）比外生型（116例）更为常见。以下特征与内生型或外生型肿瘤的临床表现均无关联：患者性别、右眼与左眼、双侧发病倾向、初始体征或症状、虹膜红变的存在、术前转移、视神经侵犯、眼眶复发、患者生存率、随访时间或诊断时年龄。发现有三个特征与类型相关：内生型视网膜母细胞瘤患者中家族史阳性的比例不成比例地更高；外生型视网膜母细胞瘤患者中患青光眼的比例不成比例地高；外生型视网膜母细胞瘤患者脉络膜侵犯的发生率明显高于内生型视网膜母细胞瘤患者。
