Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Vaccine. 2012 May 21;30(24):3572-9. doi: 10.1016/j.vaccine.2012.03.051. Epub 2012 Mar 31.
Vaccination is one of the most effective medical interventions. However, optimization of existing as well as design of new vaccines is still mostly conducted empirically; a rational approach to vaccine design is largely prohibited by the lack of insight into the relevant mechanisms underlying immune-mediated protection. To delineate the impact of variables on immune memory formation following vaccination, we took advantage of a trial assessing the role of the age of the recipient and the number of administered doses of the quadrivalent HPV vaccine in a well-characterized longitudinal cohort of girls and young women. We found that age of the recipient and the number of doses administered differentially impact the development of B and T cell memory. Specifically, age of the recipient significantly impacted generation of HPV 18-specific B cell memory, while the number of vaccine doses displayed a significant effect on the development of HPV-specific T cell memory. Our data indicate that rational design of vaccines has to be tailored according to the desired induction of B and/or T cell memory.
疫苗接种是最有效的医学干预措施之一。然而，现有疫苗的优化和新型疫苗的设计在很大程度上仍然是经验性的；由于缺乏对免疫介导保护相关机制的深入了解，理性的疫苗设计方法在很大程度上受到限制。为了阐明变量对疫苗接种后免疫记忆形成的影响，我们利用一项试验，评估了在一个经过充分特征描述的纵向女孩和年轻女性队列中，受种者年龄和接种的四价 HPV 疫苗剂量数在疫苗接种后免疫记忆形成中的作用。我们发现，受种者的年龄和接种剂量数对 B 细胞和 T 细胞记忆的产生有不同的影响。具体来说，受种者的年龄显著影响 HPV 18 特异性 B 细胞记忆的产生，而疫苗剂量数对 HPV 特异性 T 细胞记忆的产生有显著影响。我们的数据表明，疫苗的理性设计必须根据预期的 B 细胞和/或 T 细胞记忆的诱导来量身定制。
