Prabhu Priya R, Carter Joseph J, Galloway Denise A
Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Vaccines (Basel). 2022 May 25;10(6):837. doi: 10.3390/vaccines10060837.
Infection with human papillomavirus (HPV) is the necessary cause of cervical cancer. Availability of vaccines against HPV makes it a highly preventable disease. HPV vaccines act through type-specific neutralizing antibodies produced by antigen-specific plasma cells known as long-lived plasma cells (LLPC). However, just as any other vaccine, success of HPV vaccine is attributed to the immunologic memory that it builds, which is largely attained through generation and maintenance of a class of B cells named memory B cells (Bmem). Both LLPCs and Bmems are important in inducing and maintaining immune memory and it is therefore necessary to understand their role after HPV vaccination to better predict outcomes. This review summarizes current knowledge of B-cell responses following HPV vaccination and natural infection, including molecular signatures associated with these responses.
人乳头瘤病毒（HPV）感染是宫颈癌的必要病因。HPV疫苗的可获得性使其成为一种高度可预防的疾病。HPV疫苗通过由称为长寿浆细胞（LLPC）的抗原特异性浆细胞产生的型特异性中和抗体发挥作用。然而，与任何其他疫苗一样，HPV疫苗的成功归因于其建立的免疫记忆，这在很大程度上是通过一类名为记忆B细胞（Bmem）的B细胞的产生和维持来实现的。LLPC和Bmem在诱导和维持免疫记忆方面都很重要，因此有必要了解它们在HPV疫苗接种后的作用，以便更好地预测结果。本综述总结了HPV疫苗接种和自然感染后B细胞反应的现有知识，包括与这些反应相关的分子特征。
