视前区的热敏神经元调节大鼠睡眠中与环境温度相关的变化。
Warm sensitive neurons of the preoptic area regulate ambient temperature related changes in sleep in the rat.
作者信息
Kumar Deependra, Kumar Velayudhan Mohan, Mallick Hruda Nanda
机构信息
Department of Physiology, All India Institute of Medical Sciences, New Delhi - 110 029, India.
出版信息
Indian J Physiol Pharmacol. 2011 Jul-Sep;55(3):262-71.
Warm sensitive neurons (WSN) play a major role not only in body temperature regulation, but also in sleep regulation. The present study was undertaken to investigate the role of WSN of the preoptic area (POA) in mediating the ambient temperature (T(amb)) related changes in sleep. The effect of T(amb) changes on sleep and body temperature was studied in rats before and after destruction of WSN of the POA by local intracerebral injection of capsaicin. Though the rats preferred 27 degrees C T(amb), they slept maximum at 30 degrees C. After destruction of WSN of the POA, slow wave sleep (SWS) peak was brought down to 27 degrees C, which was the preferred T(amb) of the rats. This indicates that WSN of the POA mediate the increase in SWS, at temperatures higher than preferred T(amb). On the other hand, in WSN destroyed rats, rapid eye movement (REM) sleep was maximum at 33 degrees C. It suggests that the REM sleep generation is under inhibitory control of the WSN of the POA. The study supports several earlier reports that the neurons of the POA play a key role in coordinating sleep and body temperature regulation.
温敏神经元（WSN）不仅在体温调节中起主要作用，在睡眠调节中也发挥着重要作用。本研究旨在探讨视前区（POA）的温敏神经元在介导与环境温度（T(amb)）相关的睡眠变化中的作用。通过局部脑内注射辣椒素破坏POA的温敏神经元前后，研究了环境温度变化对大鼠睡眠和体温的影响。虽然大鼠偏好27摄氏度的环境温度，但它们在30摄氏度时睡眠最多。破坏POA的温敏神经元后，慢波睡眠（SWS）峰值降至27摄氏度，这是大鼠偏好的环境温度。这表明，在高于偏好环境温度时，POA的温敏神经元介导了慢波睡眠的增加。另一方面，在温敏神经元被破坏的大鼠中，快速眼动（REM）睡眠在33摄氏度时最多。这表明快速眼动睡眠的产生受POA温敏神经元的抑制性控制。该研究支持了一些早期报告，即视前区的神经元在协调睡眠和体温调节中起关键作用。
Zotero 插件