Eye Pathology Institute, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol. 2013 Jun;91(4):349-54. doi: 10.1111/j.1755-3768.2012.02403.x. Epub 2012 Apr 4.
To evaluate the incidence rate, distribution, patient characteristics and indications for surgical intervention of lacrimal gland lesions in Denmark between 1974 and 2007.
All biopsied/surgically removed lacrimal gland lesions in Denmark during the period 1974-2007 were identified by searching two population-based registries. Specimens were collected and re-evaluated. The following data were collected: age, gender, indications for surgical intervention and local recurrence.
A total of 232 lesions from 210 patients with a histologically verified lesion of the lacrimal gland were included. The incidence rate of lacrimal gland lesions was 1.3/1 000 000/year. The overall annual age- and gender-adjusted incidence rate more than doubled during the study period, owing to an increase in non-malignant lesions. Approximately half of the lesions were neoplasms (119) and 55% (66) of these were malignant. Dacryops constituted 10% (24), inflammatory lesions 27% (62), normal tissue 12% (27), benign tumours 23% (53) and malignant tumours 29% (66). Patients with malignant neoplasms were significantly older than patients with benign neoplasms (63 versus 48 years, p < 0.001). The indication for surgical intervention was suspicion of a tumour in more than 90% of the neoplastic lesions and in 30% of the non-neoplastic lesions.
Lacrimal gland lesions that require surgical evaluation are rare in the Danish population and represent a wide spectrum of diagnoses, mostly benign. The overall incidence rate of biopsied lacrimal gland lesions is increasing.
评估 1974 年至 2007 年丹麦泪腺病变的发病率、分布、患者特征和手术干预指征。
通过搜索两个基于人群的登记处，确定了丹麦在 1974 年至 2007 年间活检/手术切除的所有泪腺病变。收集并重新评估了标本。收集了以下数据：年龄、性别、手术干预指征和局部复发。
共纳入 210 例经组织学证实泪腺病变患者的 232 个病变。泪腺病变的发病率为 1.3/1000000/年。在研究期间，由于非恶性病变的增加，总体年度年龄和性别调整后的发病率增加了一倍以上。大约一半的病变为肿瘤（119 个），其中 55%（66 个）为恶性肿瘤。Dacryops 占 10%（24 个），炎症病变占 27%（62 个），正常组织占 12%（27 个），良性肿瘤占 23%（53 个），恶性肿瘤占 29%（66 个）。患有恶性肿瘤的患者明显比患有良性肿瘤的患者年龄大（63 岁比 48 岁，p < 0.001）。手术干预的指征是怀疑 90%以上的肿瘤性病变和 30%的非肿瘤性病变为肿瘤。
需要手术评估的泪腺病变在丹麦人群中较为罕见，代表了广泛的诊断，主要为良性。活检泪腺病变的总体发病率正在增加。
