Hirsch C, Holz F G, Tetz M, Völcker H E
Universitäts-Augenklinik Heidelberg.
Klin Monbl Augenheilkd. 1997 Mar;210(3):153-7. doi: 10.1055/s-2008-1035035.
Histologically the lacrimal caruncle represents a transition zone between the conjunctiva and the skin containing cutaneous, conjunctival and lacrimal elements. This accounts for a variety of histopathological changes.
We conducted a retrospective study on the histopathological findings of 65 caruncular lesions which were referred for excisional biopsy between 1974 and 1995 to the Department of Ophthalmology at the University of Heidelberg. The age of the patients ranged from 10-87 years (mean 42 +/- 18.2).
Histopathologic diagnoses included 29 (45%) nevi, 15 (23%) papillomas, 7 (11%) chronic inflammatory lesions and 4 (6%) epidermoid cysts. In addition, 4 (6%) semimalignant and malignant tumours were found including one basalioma, one squamous cell carcinoma and two Kaposi-sarcomas. Among the remaining 8% a dermoid cyst, an accessory lacrimal gland with a retention cyst, an epithelial implantation cyst, a teleangiectatic granuloma and an oncocytoma were diagnosed.
These findings suggest that malignant caruncular lesions are rare, however excisional biopsy appears prudent in order to establish the histological diagnosis.
组织学上,泪阜代表结膜与皮肤之间的过渡区域,包含皮肤、结膜和泪腺成分。这导致了多种组织病理学变化。
我们对1974年至1995年间转诊至海德堡大学眼科进行切除活检的65例泪阜病变的组织病理学结果进行了回顾性研究。患者年龄在10至87岁之间(平均42±18.2岁)。
组织病理学诊断包括29例(45%)痣、15例(23%)乳头状瘤、7例(11%)慢性炎症性病变和4例(6%)表皮样囊肿。此外,发现4例(6%)半恶性和恶性肿瘤,包括1例基底细胞瘤、1例鳞状细胞癌和2例卡波西肉瘤。在其余8%的病例中,诊断出皮样囊肿、伴有潴留囊肿的副泪腺、上皮植入性囊肿、毛细血管扩张性肉芽肿和嗜酸性细胞瘤。
这些发现表明,泪阜恶性病变罕见,但为了确立组织学诊断,切除活检似乎是谨慎的做法。