Olton D S, Raffaele K C
Department of Psychology, Johns Hopkins University, Baltimore, MD 21218.
NIDA Res Monogr. 1990;97:37-47.
Animal models provide important information about strategies that can be used to assess the effects of chronic exposure to drugs or other compounds. Furthermore, when used in conjunction with analyses designed to utilize the many advantages of animal models to examine learning and memory, these kinds of experiments can have significant ramifications for assessing the mnemonic effects of chronic drug use in people. Finally, given that aging is accompanied by significant deterioration of neurochemical systems, which may compromise the functions of those systems, the results from the experiments with DFP predict that changes in learning and memory abilities that are not apparent in young individuals may begin to surface as those individuals age or may appear following any other kind of insult to their nervous system.
动物模型为评估长期接触药物或其他化合物的策略提供了重要信息。此外，当与旨在利用动物模型的诸多优势来研究学习和记忆的分析方法结合使用时，这类实验对于评估长期药物使用对人类记忆的影响可能会产生重大影响。最后，鉴于衰老伴随着神经化学系统的显著退化，这可能会损害这些系统的功能，用二异丙基氟磷酸酯进行的实验结果预测，年轻个体中不明显的学习和记忆能力变化可能会随着个体年龄增长而开始显现，或者在其神经系统受到任何其他类型的损伤后出现。
