Pescosolido Nicola, Cavallotti Carlo, Rusciano Dario, Nebbioso Marcella
Department of Science Cardiovascular Respiratory and Morphological Sciences, Sapienza University of Rome, Rome, Italy.
Ultrastruct Pathol. 2012 Apr;36(2):102-7. doi: 10.3109/01913123.2011.634090.
The impact of glycosaminoglycans on intraocular pressure in glaucoma patients and in healthy young or aging subjects is explored.
Thirty small autoptic samples were harvested from the tissue localized around the iridocorneal angle of the eye, taking care not to cause aesthetic damage. The samples came from three groups (young, old, and subjects with glaucoma). All samples were divided in two fragments and both were used for morphological and biochemical analyses. Quantitative data were obtained from image analysis to correlate with biochemical values. All results were statistically analyzed.
The findings show the following changes of iridocorneal angle are caused by glycosaminoglycans both in aging and in glacoumatous patients: (1) deposition of fibrous granular material and increased electron density of the structures close to the iridocorneal angle; and (2) strong decrease of hyaluronic acid content and increase of sulfated glycosaminoglycans.
Similar to what happens in other tissues in the body, glycosaminoglycans of the human iridocorneal angle undergo physiological and pathological changes. The trabecular meshwork is the structure responsible for the regulation of the aqueous humor outflow that is often altered in primary open-angle glaucoma patients.
探讨糖胺聚糖对青光眼患者以及健康年轻人或老年人眼压的影响。
从眼角膜缘周围组织采集30个小型尸检样本，注意避免造成外观损伤。样本来自三组（年轻人、老年人和青光眼患者）。所有样本均分成两块，分别用于形态学和生化分析。通过图像分析获得定量数据，以便与生化值相关联。所有结果均进行统计学分析。
研究结果表明，糖胺聚糖在衰老和青光眼患者中均会导致角膜缘出现以下变化：（1）纤维颗粒物质沉积以及角膜缘附近结构的电子密度增加；（2）透明质酸含量大幅降低，硫酸化糖胺聚糖增加。
与人体其他组织的情况类似，人眼角膜缘的糖胺聚糖会发生生理和病理变化。小梁网是负责调节房水流出的结构，在原发性开角型青光眼患者中常发生改变。
