Nebbioso Marcella, Fazio Stefano, Di Blasio Dario, Pescosolido Nicola
Department of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Italy Air Force Main Medical Wing, via Caluri, 1,37069 Villafranca, Verona, Italy.
ScientificWorldJournal. 2014 Jan 16;2014:585218. doi: 10.1155/2014/585218. eCollection 2014.
The purpose of this study focused on understanding the mechanisms underlying ocular hydrodynamics and the changes which occur in the eyes of subjects exposed to hypobaric hypoxia (HH) to permit the achievement of more detailed knowledge in glaucomatous disease.
Twenty male subjects, aged 32±5 years, attending the Italian Air Force, were enrolled for this study. The research derived from hypobaric chamber, using helmet and mask supplied to jet pilotes connected to oxygen cylinder and equipped with a preset automatic mixer.
The baseline values of intraocular pressure (IOP), recorded at T1, showed a mean of 16±2.23 mmHg, while climbing up to 18,000 feet the mean value was 13.7±4.17 mmHg, recorded at T2. The last assessment was performed returning to sea level (T4) where the mean IOP value was 12.8±2.57 mmHg, with a significant change (P<0.05) compared to T1. Pachymetry values related to corneal thickness in conditions of hypobarism revealed a statistically significant increase (P<0.05).
The data collected in this research seem to confirm the increasing outflow of aqueous humor (AH) in the trabecular meshwork (TM) under conditions of HH.
本研究旨在了解眼内流体动力学的潜在机制以及暴露于低压低氧（HH）环境下受试者眼睛所发生的变化，以便更详细地了解青光眼疾病。
本研究招募了20名年龄在32±5岁的意大利空军男性受试者。该研究源自低压舱，使用提供给喷气式飞行员的头盔和面罩，连接到氧气瓶并配备预设的自动混合器。
在T1记录的眼内压（IOP）基线值显示平均为16±2.23 mmHg，而在攀升至18,000英尺时，在T2记录的平均值为13.7±4.17 mmHg。最后一次评估是在返回海平面（T4）时进行的，此时平均IOP值为12.8±2.57 mmHg，与T1相比有显著变化（P<0.05）。在低压环境下与角膜厚度相关的测厚值显示有统计学意义的增加（P<0.05）。
本研究收集的数据似乎证实了在HH条件下小梁网（TM）中房水（AH）流出增加。
