Finzi Giovanna, Micello Donata, Wizemann Giorgio, Sessa Fausto, Capella Carlo
Department of Pathology, Ospedale di Circolo, Varese, Italy.
Ultrastruct Pathol. 2012 Apr;36(2):124-9. doi: 10.3109/01913123.2011.642463.
PEComas (perivascular epithelioid cell tumors) represent a group of mesenchymal neoplasms showing characteristic morphologic, immunohistochemical, ultrastructural, and genetic features. These neoplasms are usually considered benign, being often well circumscribed by a thin capsule and showing scarce atypia. However, in some cases, they show local invasion and multiple metastases and cause the patient's death. PEComas have been found in many locations, but only 7 cases have been described in the pancreas to date. Here, the authors report an additional case of this rare neoplasm and demonstrate the HMB-45 immunoreactivity of melanosomes or premelanosomes at the ultrastructural level.
血管周上皮样细胞瘤（PEComas）是一组间质性肿瘤，具有特征性的形态学、免疫组织化学、超微结构和遗传学特征。这些肿瘤通常被认为是良性的，常常被一层薄包膜很好地包裹，且异型性少见。然而，在某些情况下，它们会出现局部侵袭和多发转移，并导致患者死亡。PEComas可见于许多部位，但迄今为止胰腺中仅报道过7例。在此，作者报告了这一罕见肿瘤的另一病例，并在超微结构水平证实了黑素小体或前黑素小体的HMB-45免疫反应性。
