Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Metab Syndr Relat Disord. 2012 Aug;10(4):280-5. doi: 10.1089/met.2011.0149. Epub 2012 Apr 3.
The aim of the current study was to elucidate the clustering pattern of metabolic syndrome components along with apolipoproteins (Apo) A-I and B in diabetic and nondiabetic subjects.
Factor analysis of conventional variables of metabolic syndrome [i.e., waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and systolic blood pressure (SBP)] with or without addition of Apo A-I and B was performed on 567 and 327 diabetic and nondiabetic subjects, respectively. Thereafter, analyses were repeated after substitution of TG and HDL-C by the TG-to-HDL-C ratio (TG/HDL-C).
Regarding conventional variables of metabolic syndrome, one or two underlying factors were identified, depending on whether lipid measures were entered as two distinct variables or as a composite measure. Apolipoproteins were consistent with a one-factor structure model of metabolic syndrome and did not change the loading pattern remarkably in nondiabetics. TG and HDL-C tended to cluster with Apo B and A-I, respectively, in different models.
The current study confirms that addition of Apo A-I and B is consistent with the one-factor model of metabolic syndrome and does not modify the loading pattern remarkably in nondiabetic subjects.
本研究旨在阐明糖尿病和非糖尿病患者代谢综合征成分与载脂蛋白（Apo）A-I 和 B 的聚类模式。
对 567 例糖尿病和 327 例非糖尿病患者分别进行了代谢综合征常规变量（即腰围、胰岛素抵抗评估的稳态模型（HOMA-IR）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和收缩压（SBP））的因子分析，或添加 Apo A-I 和 B 后进行因子分析。之后，在用 TG/HDL-C 替代 TG 和 HDL-C 后，再次进行了分析。
对于代谢综合征的常规变量，根据是否将脂质测量作为两个单独的变量或作为综合测量，确定了一个或两个潜在因素。载脂蛋白与代谢综合征的单因素结构模型一致，在非糖尿病患者中并未显著改变负荷模式。在不同的模型中，TG 和 HDL-C 分别倾向于与 Apo B 和 A-I 聚类。
本研究证实，添加 Apo A-I 和 B 与代谢综合征的单因素模型一致，在非糖尿病患者中并未显著改变负荷模式。
