Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Seizure. 2012 Jun;21(5):367-70. doi: 10.1016/j.seizure.2012.03.006. Epub 2012 Apr 1.
The purpose of this study was to investigate clinical aspects and quality of life (QOL) as risk factors for depression in patients with epilepsy. One hundred and forty outpatients with a diagnosis of epilepsy who were attending our epilepsy center participated. Patients anonymously filled out a questionnaire with clinical data related to epilepsy. Depression level was evaluated by the Hamilton Depression Rating Scale-17 (HAMD-17), and quality of life was evaluated by the Quality of Life in Epilepsy-31 (QOLIE-31). Thirty-six patients with epilepsy suffered from depression (25.7%). Complex partial seizures (OR=0.112) and number of seizure types (OR=3.773) were found to be clinical risk factors for depression. Low scores for seizure worry (OR=0.947) and social function (OR=0.947) on the QOLIE-31 increased the probability of depression in patients with epilepsy.
这项研究的目的是调查癫痫患者的临床方面和生活质量（QOL）作为抑郁的风险因素。我们的癫痫中心招募了 140 名被诊断为癫痫的门诊患者。患者匿名填写了一份与癫痫相关的临床数据问卷。抑郁程度由汉密尔顿抑郁评定量表-17（HAMD-17）评估，生活质量由癫痫生活质量-31（QOLIE-31）评估。36 名癫痫患者患有抑郁症（25.7%）。发现复杂部分性发作（OR=0.112）和发作类型数量（OR=3.773）是抑郁的临床风险因素。QOLIE-31 中发作担忧（OR=0.947）和社会功能（OR=0.947）得分低会增加癫痫患者抑郁的可能性。
