Yuki N, Yoshino H, Sato S, Miyatake T
Department of Neurology, Niigata University, Japan.
Neurology. 1990 Dec;40(12):1900-2. doi: 10.1212/wnl.40.12.1900.
We report 2 patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni enteritis. Electrophysiologic studies indicated that the predominant process was axonal degeneration of motor nerves, and clinical recovery was poor. Serum testing by thin-layer chromatography and enzyme-linked immunosorbent assay revealed that the sera from both patients contained high titers of IgG antibody against GM1 ganglioside. These cases may represent a subgroup of GBS as acute axonal polyneuropathy following C jejuni enteritis associated with anti-GM1 antibodies.
我们报告了2例空肠弯曲菌肠炎后发生吉兰-巴雷综合征（GBS）的患者。电生理研究表明，主要病变过程是运动神经的轴突变性，临床恢复较差。通过薄层色谱法和酶联免疫吸附测定进行的血清检测显示，两名患者的血清中均含有高滴度的抗GM1神经节苷脂IgG抗体。这些病例可能代表GBS的一个亚组，即空肠弯曲菌肠炎后与抗GM1抗体相关的急性轴索性多发性神经病。
