Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Eur Neurol. 2012;67(5):279-86. doi: 10.1159/000336834. Epub 2012 Apr 3.
The exact functional correlation of each hemisphere's posterior cingulate gyrus with the symptoms of Alzheimer's disease (AD) remains unknown. We attempted to evaluate the relationship between metabolite ratios in each hemisphere's posterior cingulate gyrus and cognitive deficits, using multivoxel magnetic resonance spectroscopy (MRS). We recruited 23 patients with AD, 16 patients with amnestic mild cognitive impairment and 22 cognitively normal subjects. All patients underwent multivoxel MRS in the bilateral posterior cingulate gyri. We statistically analyzed correlations between the N-acetylaspartate/creatine ratio (NAA/Cr) in each posterior cingulate gyrus and patients' raw scores on neuropsychological tests. The NAA/Cr of each posterior cingulate gyrus correlated well with the verbal learning test scores on immediate recall and delayed recall tasks. We found that the only cognitive domain to correlate with the NAA/Cr of each posterior cingulate gyrus was verbal memory. Our results did not show any significant functional difference between right and left posterior cingulate gyri.
大脑两半球后扣带回各叶与阿尔茨海默病（AD）症状的确切功能相关性尚不清楚。我们试图使用多体素磁共振波谱（MRS）来评估大脑两半球后扣带回代谢物比值与认知缺陷之间的关系。我们招募了 23 名 AD 患者、16 名遗忘型轻度认知障碍患者和 22 名认知正常的受试者。所有患者均在前扣带回双侧进行多体素 MRS。我们对每位后扣带回的 N-乙酰天门冬氨酸/肌酸比（NAA/Cr）与神经心理学测试的原始分数之间的相关性进行了统计学分析。每位后扣带回的 NAA/Cr 与即刻回忆和延迟回忆任务的词语学习测试分数密切相关。我们发现，唯一与每位后扣带回的 NAA/Cr 相关的认知领域是词语记忆。我们的结果并未显示左右后扣带回之间存在任何显著的功能差异。
