Department of Histopathology, The Christie Hospital, NHS Foundation Trust, Wilmslow Road, Manchester, UK.
Am J Surg Pathol. 2012 Jun;36(6):889-94. doi: 10.1097/PAS.0b013e31824fff50.
Thirteen cases of type A thymoma are reported showing the characteristic architectural attributes of this tumor type (World Health Organization), such as lobulation, perivascular spaces, gland-like formations, and cystic changes, but also displaying atypical features, as defined by increased mitotic activity, mild to moderate nuclear atypia, and/or scattered small foci of necrosis. The tumors were similar to type B3 thymomas in many respects, except for the fact that the tumor cells were spindled instead of round/polygonal. The existence of these cases suggests the desirability of an expansion of the type A thymoma category, analogous to that currently used for type B tumors. The various nomenclature options that could be used to name these tumors have been discussed.
报告了 13 例 A 型胸腺瘤病例，这些病例显示出这种肿瘤类型的特征性结构特征（世界卫生组织），如分叶、血管周围间隙、腺样形成和囊性改变，但也显示出非典型特征，如增加的有丝分裂活性、轻度至中度核异型性和/或散在的小灶性坏死。这些肿瘤在许多方面与 B3 型胸腺瘤相似，除了肿瘤细胞呈梭形而不是圆形/多边形这一事实。这些病例的存在表明，有必要扩大 A 型胸腺瘤的分类，类似于目前用于 B 型肿瘤的分类。已经讨论了可以用来命名这些肿瘤的各种命名选项。
