mRNA leapfrogs DNA to show promise for therapeutic gene transfer.
作者信息
Gilboa Eli
机构信息
Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
出版信息
Mol Ther. 2012 Apr;20(4):694-5. doi: 10.1038/mt.2012.31.
Abstract
摘要
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2
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.生成最佳的治疗用 mRNA：HPLC 纯化去除免疫激活并提高核苷修饰的、编码蛋白的 mRNA 的翻译效率。
Nucleic Acids Res. 2011 Nov;39(21):e142. doi: 10.1093/nar/gkr695. Epub 2011 Sep 2.
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Expression of therapeutic proteins after delivery of chemically modified mRNA in mice.化学修饰 mRNA 给药后小鼠内治疗性蛋白的表达。
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