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Do cell-penetrating peptides actually "penetrate" cellular membranes?细胞穿透肽真的能“穿透”细胞膜吗？
Mol Ther. 2012 Apr;20(4):695-7. doi: 10.1038/mt.2012.40.
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Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells.富含精氨酸的多肽诱导短暂的局灶性膜变形，导致其直接穿透细胞。
Mol Ther. 2012 May;20(5):984-93. doi: 10.1038/mt.2011.313. Epub 2012 Feb 14.
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A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E.一种新型两亲性细胞穿透肽，基于人载脂蛋白 E 的 N 端糖胺聚糖结合区。
Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):541-549. doi: 10.1016/j.bbamem.2018.12.010. Epub 2018 Dec 15.
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Current Understanding of Physicochemical Mechanisms for Cell Membrane Penetration of Arginine-rich Cell Penetrating Peptides: Role of Glycosaminoglycan Interactions.富含精氨酸的细胞穿透肽细胞膜穿透的物理化学机制的当前理解：糖胺聚糖相互作用的作用。
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Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.胍基基团的骨架刚性和静态呈现增加了富含精氨酸的细胞穿透肽的细胞摄取。
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Synergy between cell-penetrating peptides and singlet oxygen generators leads to efficient photolysis of membranes.细胞穿透肽与单线态氧发生器之间的协同作用导致膜的有效光解。
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Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice.细胞穿透肽修饰的抗 VEGF 药物局部给药缓解小鼠脉络膜新生血管化。
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Biological Properties of Arginine-rich Peptides and their Application in Cargo Delivery to Cancer.富含精氨酸肽的生物学特性及其在癌症载药中的应用。
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How Do Biomolecules Cross the Cell Membrane?生物分子如何穿过细胞膜？
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Targeting intracellular protein-protein interactions with macrocyclic peptides.靶向细胞内蛋白-蛋白相互作用的大环肽。
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本文引用的文献

1
Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells.富含精氨酸的多肽诱导短暂的局灶性膜变形，导致其直接穿透细胞。
Mol Ther. 2012 May;20(5):984-93. doi: 10.1038/mt.2011.313. Epub 2012 Feb 14.
2
Protein transduction domain delivery of therapeutic macromolecules.蛋白转导结构域递送治疗性大分子。
Curr Opin Biotechnol. 2011 Dec;22(6):888-93. doi: 10.1016/j.copbio.2011.03.008. Epub 2011 Apr 12.
3
The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake.膜修复反应掩盖了由细胞穿透肽摄取引起的膜紊乱。
FASEB J. 2009 Jan;23(1):214-23. doi: 10.1096/fj.08-110254. Epub 2008 Sep 11.
4
Blebs lead the way: how to migrate without lamellipodia.水泡引领方向：无片状伪足时如何迁移。
Nat Rev Mol Cell Biol. 2008 Sep;9(9):730-6. doi: 10.1038/nrm2453. Epub 2008 Jul 16.
5
Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans.富含精氨酸肽的细胞内化及分布与细胞外肽浓度、血清和质膜相关蛋白聚糖的关系。
Bioconjug Chem. 2008 Mar;19(3):656-64. doi: 10.1021/bc700289w. Epub 2008 Feb 13.
6
A comprehensive model for the cellular uptake of cationic cell-penetrating peptides.阳离子细胞穿透肽细胞摄取的综合模型。
Traffic. 2007 Jul;8(7):848-66. doi: 10.1111/j.1600-0854.2007.00572.x.
7
Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells.L-和D-八聚精氨酸在温度、浓度和胆固醇依赖下跨CD34+白血病细胞质膜和核膜的转运
Biochem J. 2007 Apr 15;403(2):335-42. doi: 10.1042/BJ20061808.
8
Cationic TAT peptide transduction domain enters cells by macropinocytosis.阳离子TAT肽转导结构域通过巨胞饮作用进入细胞。
J Control Release. 2005 Jan 20;102(1):247-53. doi: 10.1016/j.jconrel.2004.10.018.
9
Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement.富含精氨酸肽的细胞摄取：巨胞饮作用和肌动蛋白重排的作用
Mol Ther. 2004 Dec;10(6):1011-22. doi: 10.1016/j.ymthe.2004.08.010.
10
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.可转导的TAT-HA融合肽增强脂质筏巨胞饮作用后TAT融合蛋白的逃逸。
Nat Med. 2004 Mar;10(3):310-5. doi: 10.1038/nm996. Epub 2004 Feb 8.

Do cell-penetrating peptides actually "penetrate" cellular membranes?

作者信息

Palm-Apergi Caroline, Lönn Peter, Dowdy Steven F

机构信息

Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093, USA.

出版信息

Mol Ther. 2012 Apr;20(4):695-7. doi: 10.1038/mt.2012.40.

DOI:10.1038/mt.2012.40
PMID:22472979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3322330/
Abstract
摘要