1,2,4-三嗪和诺拉醌的三嗪并异喹啉二酮 DEF 环系的合成。
Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone.
机构信息
Department of Chemistry and Center for Chemical Methodologies and Library Development, 219 Parkman Avenue, 15260 Pittsburgh, PA, USA.
出版信息
Org Biomol Chem. 2012 Aug 14;10(30):5811-4. doi: 10.1039/c2ob25353d. Epub 2012 Apr 4.
Abstract
The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.
摘要
分子内 Staudinger-aza-Wittig 反应被用于 1,2,5,6-四氢-1,2,4-三嗪的通用合成，这是一种报道于天然产物诺拉醌的结构基序。诺拉醌的 DEF 部分通过 13 步反应以 2%的总收率得到，合成产物的结构通过 X 射线分析得到确认。
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