Kuang Liping, Liu Lok Lok, Chiu Pauline
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China).
Chemistry. 2015 Oct 5;21(41):14287-91. doi: 10.1002/chem.201502890. Epub 2015 Aug 27.
An efficient formal total synthesis of (+) cortistatins A and J has been accomplished, by exploiting a highly diastereoselective intramolecular [4+3] cycloaddition of epoxy enolsilanes as the key reaction to construct rings B and C of the cortistatins in one step.
通过利用环氧烯基硅烷的高度非对映选择性分子内[4+3]环加成反应作为关键反应，一步构建了皮质抑素的B环和C环，从而实现了(+)皮质抑素A和J的高效形式全合成。
