（+）-皮质抑素A和J的形式全合成。
Formal total synthesis of (+)-cortistatins A and J.
作者信息
Kuang Liping, Liu Lok Lok, Chiu Pauline
机构信息
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China).
出版信息
Chemistry. 2015 Oct 5;21(41):14287-91. doi: 10.1002/chem.201502890. Epub 2015 Aug 27.
PMID:26310712
Abstract
An efficient formal total synthesis of (+) cortistatins A and J has been accomplished, by exploiting a highly diastereoselective intramolecular [4+3] cycloaddition of epoxy enolsilanes as the key reaction to construct rings B and C of the cortistatins in one step.
摘要
通过利用环氧烯基硅烷的高度非对映选择性分子内[4+3]环加成反应作为关键反应，一步构建了皮质抑素的B环和C环，从而实现了(+)皮质抑素A和J的高效形式全合成。
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