Department of Child Psychiatry, University of Helsinki and Helsinki University Central Hospital, Finland.
Pharmacoepidemiol Drug Saf. 2012 Sep;21(9):964-71. doi: 10.1002/pds.3265. Epub 2012 Apr 4.
Information on who uses antipsychotic medication is limited to cross-sectional data. The objective of this study was to study the patterns of psychopathology at age 8 years and antipsychotic use between the ages of 12 and 25 years.
A total of 5525 subjects from the Finnish Nationwide 1981 birth cohort were linked to the National Prescription Register and the Hospital Discharge Register between 1994 and 2005. Information about parent-reported and teacher-reported conduct, hyperkinetic and emotional symptoms, and self-reported depressive symptoms was gathered at age 8 years. Information about antipsychotic use and about psychiatric disorders treated in hospitals between the ages of 12 and 25 years was register based. Diagnostic classes of hospital treatment included non-affective psychoses, affective disorders, and other psychiatric disorders.
The cumulative incidence of antipsychotic use by age 25 years was 2.8% among men (n = 69) and 2.1% among women (n = 55). In both sexes, living with other than two biological parents at age 8 years was associated with antipsychotic use, and three fourths of antipsychotic users had been treated for psychiatric disorders in a hospital. Among men, the most common hospital diagnosis was non-affective psychoses (44% of all antipsychotic users), and antipsychotic use was associated with childhood conduct problems. Among women, the most common hospital diagnosis was affective disorders (38% of all antipsychotic users), and antipsychotic use was associated with emotional problems and self-reported depressive symptoms in childhood.
Antipsychotic use in adolescence and young adulthood is different among men versus women both with regard to hospital diagnoses and childhood psychiatric problems.
关于使用抗精神病药物的人群的信息仅限于横断面数据。本研究的目的是研究 8 岁时的精神病理学模式和 12 至 25 岁之间使用抗精神病药物的情况。
共纳入了 5525 名来自芬兰全国 1981 年出生队列的研究对象，他们在 1994 年至 2005 年期间与国家处方登记册和住院记录进行了关联。在 8 岁时收集了父母报告和教师报告的行为、多动和情绪症状以及自我报告的抑郁症状信息。12 至 25 岁之间使用抗精神病药物和在医院治疗的精神疾病的信息是基于登记册的。住院治疗的诊断类别包括非情感性精神病、情感障碍和其他精神障碍。
到 25 岁时，男性（n=69）和女性（n=55）使用抗精神病药物的累积发生率分别为 2.8%和 2.1%。在两性中，8 岁时与除了两个生物学父母之外的人一起生活与使用抗精神病药物有关，四分之三的抗精神病药物使用者在医院接受过精神疾病治疗。在男性中，最常见的医院诊断是非情感性精神病（所有抗精神病药物使用者的 44%），抗精神病药物的使用与儿童期行为问题有关。在女性中，最常见的医院诊断是情感障碍（所有抗精神病药物使用者的 38%），抗精神病药物的使用与儿童期的情绪问题和自我报告的抑郁症状有关。
在青春期和成年早期，男性和女性使用抗精神病药物在医院诊断和儿童期精神问题方面存在差异。
