Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Quebec, Canada.
Ann Neurol. 2012 May;71(5):601-13. doi: 10.1002/ana.22693. Epub 2012 Apr 4.
Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon-glial interactions in those children destined for diagnosis of MS.
从最初表现为中枢神经系统炎症且随后可能或不可能被诊断为多发性硬化症 (MS) 的儿童中收集的脑脊液样本，进行了大规模蛋白质组学筛选。出乎意料的是，通常与 MS 相关的主要紧凑髓鞘膜蛋白并未被检测到。然而，多个定位于Ranvier 结和周围轴突-胶质器细胞膜的分子被牵连在内，表明那些注定被诊断为 MS 的儿童的轴突-胶质相互作用受到了干扰。
