Division of Transfusion Medicine and Hemostasis, Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390-9073, USA.
Am J Hematol. 2012 May;87 Suppl 1:S56-62. doi: 10.1002/ajh.23179. Epub 2012 Mar 31.
Acquired coagulopathies are often detected by laboratory investigation in clinical practice. There is a poor correlation between mild to moderate abnormalities of laboratory test and bleeding tendency. Patients who are bleeding due to coagulopathy are often managed with various blood components including plasma, platelets, and cryoprecipitate. However, prophylactic transfusion of these products in a nonbleeding patient to correct mild to moderate abnormality of a coagulation test especially preprocedure is not evidence-based. This article reviews the management of bleeding due to oral anticoagulants and antiplatelet agents, disseminated intravascular coagulation, chronic liver disease, and trauma.
获得性凝血障碍在临床实践中常通过实验室检查发现。实验室检查中轻度至中度异常与出血倾向之间相关性差。因凝血障碍而出血的患者通常使用各种血液成分（包括血浆、血小板和冷沉淀）进行治疗。然而，对于无出血的患者预防性输注这些产品以纠正凝血试验中的轻度至中度异常（特别是术前），尚无证据支持。本文回顾了口服抗凝剂和抗血小板药物、弥漫性血管内凝血、慢性肝病和创伤导致的出血的处理方法。
