缺氧诱导因子-1α（HIF-1α）与交换蛋白直接激活环一磷酸腺苷（Epac1）启动子结合，在中风后将造血干细胞招募至缺血性脑。 - Suppr

HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke.

作者信息

Lai Ted Weita, Lin Shinn-Zong, Lee Hsu-Tung, Fan Jia-Rong, Hsu Yung-Hsiang, Wang Hsiao-Jung, Yu Yung-Luen, Shyu Woei-Cherng

出版信息

J Mol Cell Biol. 2012 Jun;4(3):184-7. doi: 10.1093/jmcb/mjs009. Epub 2012 Apr 3.

DOI:10.1093/jmcb/mjs009

PMID:22474076

Abstract

摘要

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HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke.缺氧诱导因子-1α（HIF-1α）与交换蛋白直接激活环一磷酸腺苷（Epac1）启动子结合，在中风后将造血干细胞招募至缺血性脑。

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HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke.

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