青少年亨廷顿舞蹈症的当前药物治疗管理
Current Pharmacological Management in Juvenile Huntington's Disease.
作者信息
Robertson Lisa, Santini Helen, O'Donovan Kirsty L, Squitieri Ferdinando, Barker Roger A, Rakowicz Maria, Landwehrmeyer G Bernhard, Quarrell Oliver
机构信息
Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield UK S10 2TH; Neurogenetics and Rare Diseases Centre, IRCCS Neuromed, Pozzilli (IS), Italy.; University of Cambridge; Department of Clinical Neurophysiology, Institute of Psychiatry and Naurology, Warsaw, Poland and Dept. of Neurology, University of Ulm, Ulm, Germany.
出版信息
PLoS Curr. 2012 Feb 15;4:RRN1304. doi: 10.1371/currents.RRN1304.
BACKGROUND
The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.
AIM
To survey the current use of pharmacological treatments for JHD.
METHODS
Patients were identified through the HD Association, Hospital Doctors and the European Huntington's Disease Network REGISTRY study.
RESULTS
The most commonly prescribed agents were anti-psychotics (24/45), anti-depressants (17/45) and anti-parkinsonian medications (15/45). 5 patients were taking more than 8 medications.
CONCLUSIONS
The most commonly prescribed group of medication was the anti-psychotic. Many patients were on multiple therapies, highlighting the need to rationalise medications.
背景
青少年型亨廷顿舞蹈病（JHD）的临床表现可能与成人起病的亨廷顿舞蹈病（HD）有很大不同，几乎没有证据可指导症状管理。
目的
调查目前用于JHD的药物治疗情况。
方法
通过亨廷顿舞蹈病协会、医院医生和欧洲亨廷顿舞蹈病网络登记研究来确定患者。
结果
最常开具的药物是抗精神病药物（24/45）、抗抑郁药物（17/45）和抗帕金森药物（15/45）。5名患者服用的药物超过8种。
结论
最常开具的药物类别是抗精神病药物。许多患者接受多种治疗，这突出表明需要对药物进行合理调整。
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