de Prost Y, Touraine R
Ann Dermatol Venereol. 1979 Feb;106(2):109-12.
A remarkable increase in the number of recognized clinical abnormalities of neutrophil function has occurred within the 8 years past. Of major importance in the delineation of these disorders is the establishment of appropriate methodology of their characterization. This review discusses phagocytosis and its disorders by dividing it into stages that encompass the way in which phagocytes ferret out injection, how they recognize pathogens and the intracellular events leading to engulfment and killing of micro-organisms. The pathology of chemotaxis and random mobility is described: the lazy leukocyte syndrome, the Chediak-Higashi syndrome, the familial chemotaxis pecular dermatosis, and a variety of serum abnormalities of the serum complement system associated with deficient generation of chemotactic activity. The second part of these disorders is dailing with the inherited abnormalities of the oxygen dependent killing mechanisms of phagocytes, the chronic granulomatous disease, the glucose-6-phosphate deshydrogenase deficiency, the myeloperoxydase deficiency and the glutathione peroxydase deficiency.
在过去8年里，已认识到的中性粒细胞功能临床异常的数量显著增加。在描述这些疾病时，最重要的是建立适当的表征方法。本综述通过将吞噬作用及其紊乱分为几个阶段来进行讨论，这些阶段包括吞噬细胞发现感染的方式、它们识别病原体的方式以及导致微生物吞噬和杀伤的细胞内事件。还描述了趋化性和随机移动性的病理学：懒惰白细胞综合征、切-希二氏综合征、家族性趋化性特殊皮肤病以及与趋化活性产生不足相关的各种血清补体系统异常。这些疾病的第二部分涉及吞噬细胞氧依赖性杀伤机制的遗传性异常、慢性肉芽肿病、葡萄糖-6-磷酸脱氢酶缺乏症、髓过氧化物酶缺乏症和谷胱甘肽过氧化物酶缺乏症。
