Department of Pathology, Academic Block, GB Pant Hospital, Jawaharlal Nehru Marg, New Delhi 110002, India.
Brain Tumor Pathol. 2013 Jan;30(1):40-4. doi: 10.1007/s10014-012-0096-y. Epub 2012 Apr 4.
Glioosarcomas represent a rare entity of intrinsic CNS neoplasms consisting of glial and sarcomatous elements; they account for 2 % of glioblastomas. There have been few reports of metaplastic osseous transformation in gliosarcomas. Here we report a rare case of gliosarcoma with metaplastic osteoid in a 57-year-old male patient. Magnetic resonance imaging revealed a large solid cystic heterogeneous mass lesion in the left temporal lobe with peri-tumoral oedema and areas of calcification. Histology revealed a grade IV tumour with neoplastic glial and mesenchymal components with myxoid change and areas of necrosis. The sarcomatous areas contained regions of benign osteoid formation. The histogenesis of the osseous element in gliosarcomas is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell. The osseous tissue may be in the form of newly formed osteoid, benign bone tissue formation with lacunae and osteoblastic rimming, or unequivocally malignant tissue resembling an osteosarcoma.
胶质肉瘤是一种罕见的中枢神经系统内源性肿瘤，由神经胶质和肉瘤成分组成；它占胶质母细胞瘤的 2%。胶质肉瘤中有骨样变的报道很少。本文报道了一例罕见的 57 岁男性患者的胶质肉瘤伴骨样变。磁共振成像显示左颞叶有一个大的实性囊状混杂肿块病变，伴有瘤周水肿和钙化区。组织学显示为 4 级肿瘤，有肿瘤性神经胶质和间充质成分，有黏液样变和坏死区。肉瘤区含有良性骨样形成区。胶质肉瘤中骨成分的组织发生机制尚不清楚，可能是化生或来自共同前体细胞的分化。骨组织可能是新形成的类骨质、有陷窝的良性骨组织形成和成骨细胞包绕，或类似于骨肉瘤的明确恶性组织。
