School of Public Health, University of Alberta, 2040 Li Ka Shing Center, Edmonton, AB, Canada T6G 2E1.
Diabetologia. 2012 Jun;55(6):1607-18. doi: 10.1007/s00125-012-2525-1. Epub 2012 Apr 4.
Substantial evidence suggests that people with type 2 diabetes have an increased risk of developing several types of cancers. These associations may be due to a number of direct and indirect mechanisms. Observational studies of these associations, including the potential role for glucose-lowering therapy, are being increasingly reported, but face a number of methodological challenges. This paper is the first of two review papers addressing methodological aspects underpinning the interpretations of links between diabetes and cancer, and suggests potential approaches to study designs to be considered in observational studies. This paper reviews factors related to cancer incidence in the diabetic population; the second paper relates to studies of cancer mortality.
大量证据表明，2 型糖尿病患者罹患多种癌症的风险增加。这些关联可能归因于多种直接和间接机制。这些关联的观察性研究，包括降糖治疗的潜在作用，正越来越多地被报道，但面临着许多方法学挑战。本文是两篇综述论文中的第一篇，旨在探讨糖尿病与癌症之间关联的解释所依据的方法学方面，提出了在观察性研究中应考虑的研究设计的潜在方法。本文回顾了与糖尿病患者癌症发病率相关的因素；第二篇论文涉及癌症死亡率的研究。
