T cell receptor and immunoglobulin genes in hematologic malignancies.
作者信息
Reis M D, Griesser H, Mak T W
机构信息
Department of Laboratory Haematology, Sunnybrook Health Science Centre, Ont., Canada.
出版信息
Tumour Biol. 1990;11 Suppl 1:59-77. doi: 10.1159/000217677.
PMID:2247756
Abstract
In this review, we discuss the structure, organization and activation of the immunoglobulin (Ig) and T cell receptor (TCR) genes and the use of DNA probes derived from these genes as tools to determine clonality and cell lineage in hemopoietic malignancies. We also examined briefly the participation of immunoglobulin and TCR genes in chromosomal aberrations present in many lymphoproliferative disorders, often involving protooncogenes and potentially of tumorigenic consequences.
摘要
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