Hässig M, Wetli U, Suter M, Lutz H
Abteilung Ambulanz und Bestandesmedizin der Universität Zürich.
Schweiz Arch Tierheilkd. 2012 Apr;154(4):141-7. doi: 10.1024/0036-7281/a000317.
The aim of this study was to evaluate the efficiency of vaccination of young calves and to see whether maternal antibodies may influence the immunological response in calves. For this project 20 matched-pairs of cows and their offspring were selected. Of each pair, one cow received a placebo 8 and 4 weeks before term (group A) and the other was vaccinated against Feline Leucose Virus, FeLV, with Leucogen® (group B). All calves received colostrum from their respective mother shortly after birth and all calves were vaccinated with Leucogen® 10 days after birth. Blood samples from the cows and calves were taken during the whole study period (till four weeks after calf vaccination). An ELISA test was done in the lab to define the FeLV antibody concentration. 30 % of the vaccinated cows showed a seroconversion, 13 out of 20 vaccinated cows passed the antibodies onto their calves. 11 calves of group B did not convert in comparation of only 4 of group A. All seroconverted calves had low antibody concentration before their vaccination. Calves of group B with a low passive antibody level at the beginning showed a higher seroconversion as compared to calves with higher antibody concentrations of the same group. Two thirds of the calves without maternal antibodies reacted adequately to the vaccination. Therefore, an early vaccination of calves can be recommended.
本研究的目的是评估幼龄犊牛的疫苗接种效果，并观察母源抗体是否会影响犊牛的免疫反应。在这个项目中，选择了20对配对的母牛及其后代。每对中，一头母牛在预产期前8周和4周接受安慰剂（A组），另一头母牛用Leucogen®疫苗接种猫白血病病毒（FeLV）（B组）。所有犊牛在出生后不久都从各自的母亲那里获得初乳，并且所有犊牛在出生后10天用Leucogen®疫苗接种。在整个研究期间（直到犊牛接种疫苗后四周）采集母牛和犊牛的血样。在实验室进行ELISA试验以确定FeLV抗体浓度。30%的接种疫苗的母牛出现血清转化，20头接种疫苗的母牛中有13头将抗体传递给了它们的犊牛。B组的11头犊牛没有转化，而A组只有4头。所有血清转化的犊牛在接种疫苗前抗体浓度都很低。与同一组中抗体浓度较高的犊牛相比，开始时被动抗体水平较低的B组犊牛血清转化率更高。三分之二没有母源抗体的犊牛对疫苗接种反应良好。因此，建议对犊牛进行早期接种。
