双疾病基因座模型：利用核心家庭中两个标记的信息进行分离分析。应用于胰岛素依赖型糖尿病。

Two-disease-locus model: segregation analysis using information on two markers in nuclear families. Application to IDDM.

作者信息

Dizier M H, Clerget-Darpoux F, Hochez J

机构信息

Unité de Recherches d'Epidémiologique Génétique (I.N.S.E.R.M. U. 155), Paris, France.

出版信息

Tissue Antigens. 1990 Jul;36(1):1-7. doi: 10.1111/j.1399-0039.1990.tb01790.x.

DOI:10.1111/j.1399-0039.1990.tb01790.x

PMID:2247883

Abstract

In the present paper, an extension of segregation analysis is proposed using information on the joint segregation of two unlinked markers conditional on the disease status in nuclear families, in order to consider two-locus models with one locus linked to the first marker and the other linked to the second marker. We propose tests for examining evidence for the effect of genes located at these two loci and whether this effect is multiplicative or not. This method is then applied to a sample of IDDM families typed for the HLA and Gm markers to test, in addition to a factor of the HLA region, the potential involvement of the Gm system in the susceptibility to IDDM. The analysis does not provide evidence for such an involvement.

摘要

在本文中，我们提出了一种分离分析的扩展方法，该方法利用核心家庭中基于疾病状态的两个不连锁标记的联合分离信息，以考虑一个位点与第一个标记连锁而另一个位点与第二个标记连锁的双位点模型。我们提出了一些检验，以检查位于这两个位点的基因效应的证据，以及这种效应是否具有相乘性。然后将该方法应用于一组针对HLA和Gm标记进行分型的IDDM家庭样本，除了检验HLA区域的一个因素外，还检验Gm系统在IDDM易感性中的潜在作用。分析未提供这种作用的证据。