Dizier M H, Clerget-Darpoux F, Hochez J
Unité de Recherches de Génétique Epidemiologique (INSERM U155), Paris, France.
Genet Epidemiol. 1989;6(1):71-5. doi: 10.1002/gepi.1370060114.
The purpose of our study was to examine evidence for the role of a second genetic factor in the susceptibility to IDDM, in addition to that located in the HLA region. To do this, we have studied the joint segregation of HLA and another marker conditional on disease status using the IDDM families of GAW5, under a two-locus model, one locus in the HLA region, the other close to the other marker. This marker has been, successively, Gm and the DNA polymorphism of the insulin gene 5' region. The study has been carried out using a segregation analysis method developed to make use of information on the segregation of two markers and the disease in nuclear families. The GAW5 data do not provide evidence for the role of a genetic factor in the Gm or insulin region in the etiology of IDDM.
我们研究的目的是，除位于HLA区域的基因因素外，检验是否存在另一种基因因素在胰岛素依赖型糖尿病（IDDM）易感性中发挥作用的证据。为此，我们在双位点模型（一个位点位于HLA区域，另一个位点靠近另一标记物）下，利用GAW5的IDDM家系，研究了基于疾病状态的HLA与另一个标记物的联合分离情况。该标记物先后为Gm和胰岛素基因5'区域的DNA多态性。本研究采用了一种分离分析方法，该方法旨在利用核心家庭中两个标记物和疾病的分离信息。GAW5数据未提供Gm或胰岛素区域的基因因素在IDDM病因学中发挥作用的证据。
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