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3
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Dement Geriatr Cogn Disord. 2009;27(1):88-95. doi: 10.1159/000193628. Epub 2009 Jan 21.
5
Natriuretic peptides.利钠肽
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Homocysteine, cystatin C and N-terminal-pro brain natriuretic Peptide. Vascular risk markers in elderly patients with mental illness.同型半胱氨酸、胱抑素C和N末端脑钠肽前体。老年精神疾病患者的血管风险标志物。
Dement Geriatr Cogn Disord. 2008;25(1):88-96. doi: 10.1159/000111994. Epub 2007 Dec 5.
7
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使用N端前脑钠肽评估老年精神疾病患者的血管疾病。

The use of N-terminal pro-brain natriuretic Peptide to evaluate vascular disease in elderly patients with mental illness.

作者信息

Nilsson Karin, Gustafson Lars, Hultberg Björn

机构信息

Department of Geriatric Psychiatry, Clinical Science, Lund University Hospital, Lund, Sweden.

出版信息

Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):10-8. doi: 10.1159/000334997. Epub 2012 Feb 3.

DOI:10.1159/000334997
PMID:22479261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318927/
Abstract

BACKGROUND

Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) is regarded as a sensitive marker of cardiovascular disease. Vascular disease plays an important role in cognitive impairment.

METHOD

In 447 elderly patients with mental illness, serum NT-proBNP level and the presence or absence of vascular disease according to the medical record were used to categorize patients in different subgroups of vascular disease.

RESULTS AND CONCLUSION

Patients with vascular disease and elevated serum NT-proBNP level had a lower cognition level, shorter survival time, lower renal function and a higher percentage of pathological brain imaging than patients with vascular disease and normal NT-proBNP level. Thus, elevated serum NT-proBNP level might be helpful to detect patients who have a more severe cardiovascular disease.

摘要

背景

血清N端前脑钠肽（NT-proBNP）被视为心血管疾病的敏感标志物。血管疾病在认知障碍中起重要作用。

方法

在447例老年精神疾病患者中，根据病历记录中的血清NT-proBNP水平及是否存在血管疾病，将患者分为不同的血管疾病亚组。

结果与结论

与血管疾病且NT-proBNP水平正常的患者相比，患有血管疾病且血清NT-proBNP水平升高的患者认知水平较低、生存时间较短、肾功能较低且脑影像学病理改变的比例较高。因此，血清NT-proBNP水平升高可能有助于检测患有更严重心血管疾病的患者。