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本文引用的文献

1
Clinical benefits and considerations of bisphosphonate treatment in metastatic bone disease.双膦酸盐治疗转移性骨病的临床益处及注意事项。
Semin Oncol. 2007 Dec;34(6 Suppl 4):S17-23. doi: 10.1053/j.seminoncol.2007.10.006.
2
Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research.双膦酸盐相关颌骨骨坏死：美国骨与矿物质研究学会特别工作组报告
J Bone Miner Res. 2007 Oct;22(10):1479-91. doi: 10.1359/jbmr.0707onj.
3
Imaging of periosteal osteosarcoma: radiologic-pathologic comparison.骨膜骨肉瘤的影像学表现：放射学与病理学对照
Radiology. 2004 Oct;233(1):129-38. doi: 10.1148/radiol.2331030326. Epub 2004 Aug 27.
4
MELORHEOSTOSIS. REVIEW OF THE LITERATURE AND REPORT OF AN INTERESTING CASE WITH A NINETEEN-YEAR FOLLOW-UP.肢骨纹状肥大症。文献综述及一例随访19年的有趣病例报告。
J Bone Joint Surg Am. 1963 Sep;45:1191-206.
5
Increased procollagen alpha1(I) mRNA expression by dermal fibroblasts in melorheostosis.肥大性骨关节病中真皮成纤维细胞前胶原α1（I）mRNA表达增加。
Br J Dermatol. 2003 Apr;148(4):799-803. doi: 10.1046/j.1365-2133.2003.05247.x.
6
Zoledronic acid (Zometa) use in bone disease.
Expert Rev Anticancer Ther. 2003 Apr;3(2):157-66. doi: 10.1586/14737140.3.2.157.
7
Occurrence of osteosarcoma in a melorheostotic femur.
Ir Med J. 2003 Feb;96(2):55-6.
8
Atypical form of active melorheostosis and its treatment with bisphosphonate.
Skeletal Radiol. 2002 Dec;31(12):709-13. doi: 10.1007/s00256-002-0576-y. Epub 2002 Oct 29.
9
Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid.双膦酸盐化合物唑来膦酸的新型抗血管生成作用。
J Pharmacol Exp Ther. 2002 Sep;302(3):1055-61. doi: 10.1124/jpet.102.035295.
10
Advanced imaging of melorheostosis with emphasis on MRI.骨肥大症的高级影像学检查，重点是磁共振成像。
Skeletal Radiol. 2001 Aug;30(8):447-53. doi: 10.1007/s002560100366.

骨肥大症及其静脉注射唑来膦酸治疗

Melorheostosis and its treatment with intravenous zoledronic acid.

作者信息

Hollick Rosemary Jane, Black Alison, Reid David

机构信息

Aberdeen Royal Infirmary, Department of Rheumatology, Ward 3, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK.

出版信息

BMJ Case Rep. 2010;2010. doi: 10.1136/bcr.04.2009.1757. Epub 2010 Apr 5.

DOI:10.1136/bcr.04.2009.1757
PMID:22479293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3047172/
Abstract

We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. The middle-aged man presented with pain and swelling of his tibia, which was diagnosed by imaging and bone biopsy as being due to melorheostosis. There was early symptom control after a single infusion of intravenous zoledronic acid. Prolonged symptom relief was accompanied by long-term suppression of the bone resorption marker β cross-laps. We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker.

摘要

我们报告了一例骨肥大症病例，这是一种以中胚层发育异常为特征的罕见骨病，以及使用静脉注射双膦酸盐唑来膦酸对其进行成功且长期治疗的情况。该中年男性表现为胫骨疼痛和肿胀，经影像学和骨活检诊断为骨肥大症所致。单次静脉注射唑来膦酸后早期症状得到控制。长期症状缓解伴随着骨吸收标志物β-交联羧基端肽的长期抑制。我们认为骨肥大症可用静脉注射唑来膦酸治疗，且可通过使用特定的骨吸收标志物来监测治疗效果。