骨肥大症及其静脉注射唑来膦酸治疗
Melorheostosis and its treatment with intravenous zoledronic acid.
作者信息
Hollick Rosemary Jane, Black Alison, Reid David
机构信息
Aberdeen Royal Infirmary, Department of Rheumatology, Ward 3, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK.
出版信息
BMJ Case Rep. 2010;2010. doi: 10.1136/bcr.04.2009.1757. Epub 2010 Apr 5.
Abstract
We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. The middle-aged man presented with pain and swelling of his tibia, which was diagnosed by imaging and bone biopsy as being due to melorheostosis. There was early symptom control after a single infusion of intravenous zoledronic acid. Prolonged symptom relief was accompanied by long-term suppression of the bone resorption marker β cross-laps. We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker.
摘要
我们报告了一例骨肥大症病例，这是一种以中胚层发育异常为特征的罕见骨病，以及使用静脉注射双膦酸盐唑来膦酸对其进行成功且长期治疗的情况。该中年男性表现为胫骨疼痛和肿胀，经影像学和骨活检诊断为骨肥大症所致。单次静脉注射唑来膦酸后早期症状得到控制。长期症状缓解伴随着骨吸收标志物β-交联羧基端肽的长期抑制。我们认为骨肥大症可用静脉注射唑来膦酸治疗，且可通过使用特定的骨吸收标志物来监测治疗效果。
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