Kumar Santosh, Singh Akrity, Prasad Rajeev Ranjan
Department of Biochemistry, Patna Medical College and Hospital, Patna 800004.
J Indian Med Assoc. 2011 Sep;109(9):657-8, 665.
Vitiligo is in most cases diagnosed clinically, so obvious are the features of a well developed lesion of this disease. Other investigations are rarely required. However, occasionally vitiligo especially in its early evolving stage or in some of its localised expressions may pose diagnostic difficulties as the lesions are hypopigmented rather than depigmented and other differential diagnoses may be considered. The histopathological changes in vitiligo in sections stained with haematoxylin and eosin (H&E) are often very subtle and may be inconclusive. Special staining procedures like the Fontana-Masson staining may help in reaching a definite diagnosis. The DOPA reaction which demonstrates viable and functional melanocytes may also be used but is technically difficult to perform.
白癜风在大多数情况下是通过临床诊断的，这种疾病典型病变的特征非常明显。很少需要其他检查。然而，偶尔白癜风，尤其是在其早期演变阶段或某些局限性表现中，可能会造成诊断困难，因为病变是色素减退而非色素脱失，可能需要考虑其他鉴别诊断。用苏木精和伊红（H&E）染色的切片中，白癜风的组织病理学变化通常非常细微，可能无法得出结论。像Fontana-Masson染色这样的特殊染色程序可能有助于做出明确诊断。显示存活且有功能的黑素细胞的多巴反应也可使用，但技术上难以操作。
