Nanjing University of Chinese Medicine, Department of Pharmacy, Nanjing 210046, PR China.
Expert Opin Drug Deliv. 2012 Jun;9(6):649-56. doi: 10.1517/17425247.2012.679261. Epub 2012 Apr 16.
Hepatic-targeted drug delivery systems are designed to treat diseases of the liver. However, since there are several different types of liver diseases that are caused by different cells, it is important to select the proper materials to target these different cells.
This review addresses novel materials that possess the ability to target liver cells via receptor-ligand processes and offers an insight into the aspects of formulation design. It also discusses several approaches used to enhance the targeting efficiency of drug delivery systems to receptors in the liver cells. In addition, the delivery efficiency and therapeutic efficacy of these materials in the treatment of acute or chronic liver diseases is highlighted.
Further research into the use of clinical materials and the design of smart materials for multi-drug delivery to different organelles is important for future studies on these new materials. It is hoped that these targeted therapeutics will benefit patients with liver disorders in the near future.
肝靶向药物递送系统旨在治疗肝脏疾病。然而，由于有几种不同类型的肝脏疾病是由不同的细胞引起的，因此选择合适的材料来靶向这些不同的细胞是很重要的。
本篇综述讨论了新型材料，这些材料通过受体-配体过程具有靶向肝细胞的能力，并深入探讨了制剂设计的各个方面。它还讨论了几种用于提高药物递送系统靶向肝细胞受体的靶向效率的方法。此外，还强调了这些材料在治疗急性或慢性肝病中的递送效率和治疗效果。
进一步研究临床材料的应用和智能材料的设计，以实现多药物向不同细胞器的递释，对于这些新材料的未来研究非常重要。希望这些靶向治疗剂能在不久的将来使肝脏疾病患者受益。
